abstract：:Acinetobacter baumannii has been associated with several severe hospital-acquired infections such as ventilator-associated pneumonia and meningitis. Sulbactam, a β-lactamase inhibitor, is usually combined with β-lactam antibiotics to treat infections. It has been found that sulbactam alone may be used to treat infecti...

journal_title：International journal of antimicrobial agents

authors： Lin CH,Su SC,Ho KH,Hsu YW,Lee KR

更新日期：2014-07-01 00:00:00

abstract：:The pharmacodynamic profile of modithromycin (EDP-420, EP-013420, S-013420), a novel bicyclolide, was evaluated in a neutropenic pneumococcal murine pneumonia model. Streptococcus pneumoniae median minimum inhibitory concentrations (MICs) for five genotypically diverse isolates ranged from 0.016 μg/mL to 0.125 μg/mL a...

journal_title：International journal of antimicrobial agents

authors： Maglio D,Sun HK,Patel T,Banevicius MA,Nightingale CH,Arya A,Wang G,Chen Z,Phan LT,Nicolau DP

更新日期：2014-06-01 00:00:00

abstract：:Amphotericin B is a powerful polyene antifungal drug used for treating systemic fungal infections and is usually administered for a short period. Side effects after prolonged use are unknown in humans. Here we report the case of a 28-year-old man suffering from chronic granulomatous disease (CGD), treated for invasive...

journal_title：International journal of antimicrobial agents

authors： Michot JM,Gubavu C,Fourn E,Maigne G,Teicher E,Angoulvant A,Blanche S,Lortholary O,Coilly A,Duclos-Vallée JC,Sebagh M,Guettier C,Aumont C,Delfraissy JF,Lambotte O

更新日期：2014-06-01 00:00:00

abstract：:Piperacillin plasma concentrations are known to vary between critically ill patients. However, there are no comprehensive data on the variability of antibiotic concentrations within the same patient. The purpose of this study was to investigate the adequacy of dosing during an entire 7-day antibiotic course and to inv...

journal_title：International journal of antimicrobial agents

authors： Carlier M,Carrette S,Stove V,Verstraete AG,De Waele JJ

更新日期：2014-05-01 00:00:00

abstract：:We report the results of 8 years (2005-2012) of the Daptomycin Surveillance Programme Worldwide. Consecutive non-duplicate bacterial isolates (prevalence design) were collected from patients with documented infections in 410 medical centres and were susceptibility tested by reference broth microdilution methods. A tot...

journal_title：International journal of antimicrobial agents

authors： Sader HS,Farrell DJ,Flamm RK,Jones RN

更新日期：2014-05-01 00:00:00

abstract：:Biofilms are complex bacterial structures protected by a self-produced polymer matrix that enables survival in hostile environments. Biofilms are more resistant to antibiotics than their planktonic counterparts and are therefore more difficult to eradicate. The aim of this study was to investigate the influence of van...

journal_title：International journal of antimicrobial agents

authors： Reiter KC,Sant'Anna FH,d'Azevedo PA

更新日期：2014-03-01 00:00:00

abstract：:Rifaximin, a non-absorbable rifamycin derivative, has published clinical efficacy in the alleviation of symptoms in patients with irritable bowel syndrome (IBS). Small intestinal bacterial overgrowth (SIBO) is associated with the pathogenesis of IBS. This study describes for the first time the antimicrobial effect of ...

journal_title：International journal of antimicrobial agents

authors： Pistiki A,Galani I,Pyleris E,Barbatzas C,Pimentel M,Giamarellos-Bourboulis EJ

更新日期：2014-03-01 00:00:00

abstract：:Triple therapy combining the protease inhibitor telaprevir with interferon-α and ribavirin is a promising new option for long-term treatment of hepatitis C. The interaction potential of telaprevir has not yet been fully elucidated. The in vitro potency of telaprevir to inhibit P-glycoprotein (P-gp, ABCB1) and breast c...

journal_title：International journal of antimicrobial agents

authors： Weiss J,Becker JP,Haefeli WE

更新日期：2014-02-01 00:00:00

abstract：:This study was designed to evaluate the potential role of fosfomycin as a therapeutic agent in human listeriosis. The in vitro activity of fosfomycin against 154 Listeria monocytogenes clinical isolates under conditions that mimic the induction of prfA expression was determined and was correlated with fosfomycin intra...

journal_title：International journal of antimicrobial agents

authors： Lepe JA,Torres MJ,Smani Y,Parra-Millán R,Pachón J,Vazquez-Barba I,Aznar J

更新日期：2014-02-01 00:00:00

abstract：:The objective of the present study was to compare the activities of regimens containing linezolid (LZD) with those not containing LZD against Mycobacterium tuberculosis infection in mice. The three regimens excluding LZD selected in this study are often used in practice against multidrug-resistant tuberculosis (MDR-TB...

journal_title：International journal of antimicrobial agents

authors： Zhao W,Guo Z,Zheng M,Zhang J,Wang B,Li P,Fu L,Liu S

更新日期：2014-02-01 00:00:00

abstract：:The purpose of this report was to compare two different methods for dose optimisation of antimicrobials. The probability of target attainment (PTA) was calculated using Monte Carlo simulation to predict the PK/PD target of fT>MIC or modelling and simulation of time-kill curve data. Ceftobiprole, the paradigm compound,...

journal_title：International journal of antimicrobial agents

authors： Barbour AM,Schmidt S,Zhuang L,Rand K,Derendorf H

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study was to evaluate the in vitro efficacy of ceftobiprole and comparator antibiotics, either alone or in combination, in staphylococcal MBEC™ (minimum biofilm eradication concentration) and colony biofilm assays at dilutions of the maximum free-drug plasma concentration attained during clinical use (...

journal_title：International journal of antimicrobial agents

authors： Abbanat D,Shang W,Amsler K,Santoro C,Baum E,Crespo-Carbone S,Lynch AS

更新日期：2014-01-01 00:00:00

abstract：:Cefepime is administered as an intermittent infusion (II); however, continuous infusion (CI) may be advantageous because β-lactam antibiotics exhibit time-dependent antibacterial activity. This retrospective, non-randomised, comparative study included 68 neurosurgical patients with post-operative intracranial infectio...

journal_title：International journal of antimicrobial agents

authors： Huang H,Huang S,Zhu P,Xi X

更新日期：2014-01-01 00:00:00

abstract：:Escherichia coli O25b-B2-ST131 isolates harbouring bla(CTX-M-15) are distributed worldwide. The bla(CTX-M-15) transposition unit has often been found on plasmids and the genetic contexts have been examined; however, less is known about the frequency and contexts of the bla(CTX-M-15) transposition unit on the chromosom...

journal_title：International journal of antimicrobial agents

authors： Hirai I,Fukui N,Taguchi M,Yamauchi K,Nakamura T,Okano S,Yamamoto Y

更新日期：2013-12-01 00:00:00

abstract：:Carbapenem-resistant Acinetobacter baumannii has spread rapidly across China and is currently reported to be a worldwide nosocomial menace. In light of its increasing clinical significance, this study aimed to investigate the molecular epidemiology of carbapenem-resistant and carbapenem-susceptible isolates obtained f...

journal_title：International journal of antimicrobial agents

authors： Ruan Z,Chen Y,Jiang Y,Zhou H,Zhou Z,Fu Y,Wang H,Wang Y,Yu Y

更新日期：2013-10-01 00:00:00

abstract：:As treatment options for critically ill patients with multidrug-resistant bacteria diminish, older antibiotics such as fosfomycin are being investigated for use as last-resort drugs. Fosfomycin is a broad-spectrum antibiotic with activity both against Gram-positive and Gram-negative bacteria. The aim of this review wa...

journal_title：International journal of antimicrobial agents

authors： Parker S,Lipman J,Koulenti D,Dimopoulos G,Roberts JA

更新日期：2013-10-01 00:00:00

abstract：:New initiatives have been introduced in Europe and the USA to encourage more rapid development of antibiotics. The need to ensure these new antibiotics can be safely used in children, and especially neonates, is important owing to high antimicrobial resistance in these patient groups. This review aims to determine wha...

journal_title：International journal of antimicrobial agents

authors： Garazzino S,Lutsar I,Bertaina C,Tovo PA,Sharland M

更新日期：2013-08-01 00:00:00

abstract：:This study aimed to identify factors associated with virological response (VR) to raltegravir (RAL)-containing regimens in 468 treatment-experienced but integrase inhibitor-naive HIV-1 patients receiving a RAL-containing regimen. VR was defined at Month 6 (M6) as HIV-1 RNA viral load (VL) <50 copies/mL. The impacts on...

journal_title：International journal of antimicrobial agents

authors： Marcelin AG,Delaugerre C,Beaudoux C,Descamps D,Morand-Joubert L,Amiel C,Schneider V,Ferre V,Izopet J,Si-Mohamed A,Maillard A,Henquell C,Desbois D,Lazrek M,Signori-Schmuck A,Rogez S,Yerly S,Trabaud MA,Plantier JC,Fou

更新日期：2013-07-01 00:00:00

abstract：:The tet(X) gene encodes a flavin-dependent monooxygenase that confers resistance to all clinically relevant tetracycline antibiotics including tigecycline. It has only previously been identified in environmental and non-human pathogenic bacteria. To investigate levels of multidrug resistance in Bo, Sierra Leone, a mol...

journal_title：International journal of antimicrobial agents

authors： Leski TA,Bangura U,Jimmy DH,Ansumana R,Lizewski SE,Stenger DA,Taitt CR,Vora GJ

更新日期：2013-07-01 00:00:00

abstract：:Photobacterium damselae subsp. piscicida, a causative agent of pseudotuberculosis, often harbours resistance plasmids (R plasmids) that facilitate horizontal gene transfer of drug resistance genes. R plasmid pP9014 was isolated from P. damselae subsp. piscicida and its complete nucleotide sequence was determined using...

journal_title：International journal of antimicrobial agents

authors： del Castillo CS,Jang HB,Hikima J,Jung TS,Morii H,Hirono I,Kondo H,Kurosaka C,Aoki T

更新日期：2013-07-01 00:00:00

abstract：:Antibiotic treatment represents a mainstay of therapy for clinical sepsis. Distinct from their antimicrobial effects, antibiotics may impact the inflammatory process in sepsis, e.g. within the intestinal microcirculation. The impact of seven antibiotics relevant to clinical sepsis on intestinal leukocyte recruitment a...

journal_title：International journal of antimicrobial agents

authors： Al-Banna NA,Pavlovic D,Bac VH,Utpatel K,Janke E,Rippke JN,Borowiak M,Cerny V,Spassov A,Johnston B,Issekutz TB,Lehmann CH

更新日期：2013-06-01 00:00:00

abstract：:Around the world, Staphylococcus aureus remains a dominant cause of bacteraemia. Whilst meticillin resistance remains the major phenotype of concern, various levels of reduced glycopeptide susceptibility are emerging with increasing frequency. The most common MRSA phenotypes now have raised vancomycin MICs within the ...

journal_title：International journal of antimicrobial agents

authors： Gould IM

更新日期：2013-06-01 00:00:00

abstract：:Resistance to extended-spectrum β-lactams is increasing worldwide among Escherichia coli and has been linked to a small number of emergent clones (e.g. ST38, ST131 and ST405) recovered from extraintestinal infections in community and hospital settings. There are, however, limited data about the relative contributions ...

journal_title：International journal of antimicrobial agents

authors： Weissman SJ,Adler A,Qin X,Zerr DM

更新日期：2013-05-01 00:00:00

abstract：:Antimicrobial resistance is a concern both for animal and human health. Veterinary programmes monitoring resistance of animal and zoonotic pathogens are therefore essential. Various European countries have implemented national surveillance programmes, particularly for zoonotic and commensal bacteria, and the European ...

journal_title：International journal of antimicrobial agents

authors： de Jong A,Thomas V,Klein U,Marion H,Moyaert H,Simjee S,Vallé M

更新日期：2013-05-01 00:00:00

abstract：:Linezolid is the first available oxazolidinone, possessing broad-spectrum activity against Gram-positive bacteria and a favourable pharmacokinetic profile. The aim of this study was to compare the efficacy and safety of linezolid with vancomycin, the gold-standard treatment, for meticillin-resistant Staphylococcus aur...

journal_title：International journal of antimicrobial agents

authors： An MM,Shen H,Zhang JD,Xu GT,Jiang YY

更新日期：2013-05-01 00:00:00

abstract：:Although cephalosporins are recommended as primary agents, moxifloxacin may be a suitable second-line antibiotic in cardiac surgery, especially if additional Gram-negative coverage is warranted. Cardiopulmonary bypass (CPB) may alter the pharmacokinetics of drugs in numerous ways. Since no such data exist, the aim of ...

journal_title：International journal of antimicrobial agents

authors： Wiesner G,Martin K,Gertler R,Braun SL,Tassani P,Lange R,Gruber M

更新日期：2013-05-01 00:00:00

abstract：:A restrictive antibiotic policy banning routine use of ceftriaxone and ciprofloxacin was implemented in a 450-bed district general hospital following an educational campaign. Monthly consumption of nine antibiotics was monitored in defined daily doses (DDDs) per 1000 patient-occupied bed-days (1000 pt-bds) 9 months be...

journal_title：International journal of antimicrobial agents

authors： Dancer SJ,Kirkpatrick P,Corcoran DS,Christison F,Farmer D,Robertson C

更新日期：2013-02-01 00:00:00

abstract：:Although the vancomycin minimum inhibitory concentration (VMIC) susceptibility breakpoint for Staphylococcus aureus was recently lowered to ≤2 mg/L, it is argued that isolates in the higher levels of the susceptible range may bear adverse clinical outcomes. Clinical outcomes (all-cause mortality and treatment failure)...

journal_title：International journal of antimicrobial agents

authors： Mavros MN,Tansarli GS,Vardakas KZ,Rafailidis PI,Karageorgopoulos DE,Falagas ME

更新日期：2012-12-01 00:00:00

abstract：:The purpose of this study was (i) to determine the optimal dosage of teicoplanin for each patient group stratified by renal function and weight based on a population pharmacokinetic model and observed distribution of patient characteristics and (ii) to develop new simplified dosing regimens designed to achieve 15-30 μ...

journal_title：International journal of antimicrobial agents

authors： Yamada T,Nonaka T,Yano T,Kubota T,Egashira N,Kawashiri T,Oishi R

更新日期：2012-10-01 00:00:00

abstract：:Salicylidene acylhydrazide compounds have been shown to inhibit bacterial pathogens, including Chlamydia and Neisseria gonorrhoeae. If such compounds could also target HIV-1, their potential use as topical microbicides to prevent sexually transmitted infections would be considerable. In this study, the in vitro anti-H...

journal_title：International journal of antimicrobial agents

authors： Forthal DN,Phan TB,Slepenkin AV,Landucci G,Chu H,Elofsson M,Peterson E

更新日期：2012-10-01 00:00:00

abstract：:Nasal colonisation with Staphylococcus aureus is a risk factor for invasive infection in human immunodeficiency virus (HIV)-positive individuals. This study aimed to characterise colonising S. aureus from regions with a high HIV prevalence. Single nasal swabs were taken from a total of 374 HIV-positive and 370 healthy...

journal_title：International journal of antimicrobial agents

authors： Olalekan AO,Schaumburg F,Nurjadi D,Dike AE,Ojurongbe O,Kolawole DO,Kun JF,Zanger P

更新日期：2012-09-01 00:00:00

abstract：:The detrimental effects of biofilms are a cause of great concern in medical, industrial and environmental areas. In this study, we proposed a novel eradication strategy consisting of the combined use of micropatterned surfaces and antibiotics on biofilms to reduce the rate of bacterial colonisation. Pseudomonas fluore...

journal_title：International journal of antimicrobial agents

authors： Díaz C,Miñán A,Schilardi PL,Fernández Lorenzo de Mele M

更新日期：2012-09-01 00:00:00

abstract：:We have previously demonstrated a potent in vitro inhibitory activity for two pentacyano(isoniazid)ferrate(II) compounds, namely IQG-607 and IQG-639, against the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase enzyme. In this study, the activity of these compounds was evaluated using an in vivo murine ...

journal_title：International journal of antimicrobial agents

authors： Rodrigues-Junior VS,Dos Santos Junior A,Dos Santos AJ,Schneider CZ,Calixto JB,Sousa EH,de França Lopes LG,Souto AA,Basso LA,Santos DS,Campos MM

更新日期：2012-08-01 00:00:00

abstract：:There is a lack of surveillance data on resistance to fusidic acid (FA) in Asia, and no reviews of FA usage for the treatment of orthopaedic infections have been conducted since the year 2000. In this study, we present a systemic literature review of FA resistance in Asia and the clinical use of FA for the treatment o...

journal_title：International journal of antimicrobial agents

authors： Wang JL,Tang HJ,Hsieh PH,Chiu FY,Chen YH,Chang MC,Huang CT,Liu CP,Lau YJ,Hwang KP,Ko WC,Wang CT,Liu CY,Liu CL,Hsueh PR

更新日期：2012-08-01 00:00:00

abstract：:The ability of antibiotics used in bronchopulmonary infections in cystic fibrosis (CF) patients to prevent Pseudomonas aeruginosa early biofilm formation was studied using a biofilm microtitre assay with 57 non-mucoid P. aeruginosa isolates (44 first colonisers and 13 recovered during the initial intermittent colonisa...

journal_title：International journal of antimicrobial agents

authors： Fernández-Olmos A,García-Castillo M,Maiz L,Lamas A,Baquero F,Cantón R

更新日期：2012-08-01 00:00:00

abstract：:Nosocomial infections caused by multidrug-resistant (MDR) microorganisms are a common problem around the world, especially in Intensive Care Units. The aim of this study was to investigate the efficacy and safety of colistin therapy in paediatric patients with severe nosocomial infections caused by MDR Gram-negative b...

journal_title：International journal of antimicrobial agents

authors： Paksu MS,Paksu S,Karadag A,Sensoy G,Asilioglu N,Yildizdas D,Akyildiz BN,Kendirli T,Demirkol D,Akgun M,Alp E,Ciftci E,Guney AK,Murat N

更新日期：2012-08-01 00:00:00

abstract：:The emergence of multidrug-resistant (MDR) Pseudomonas aeruginosa isolates producing IMP-type metallo-β-lactamases (MBLs) and aminoglycoside 6'-N-acetyltransferase [AAC(6')-Iae] has become a serious problem in medical settings in Japan. A total of 217 MDR P. aeruginosa isolates were obtained from August 2009 to April ...

journal_title：International journal of antimicrobial agents

authors： Kitao T,Tada T,Tanaka M,Narahara K,Shimojima M,Shimada K,Miyoshi-Akiyama T,Kirikae T

更新日期：2012-06-01 00:00:00

abstract：:The search for new nucleoside analogue compounds targeting the virally encoded reverse transcriptase was developed by modifying the nucleoside structure to create inhibitor compounds. In this review, the structure-activity relationship of antiviral compounds synthesised from the naturally existing cytosine deoxyribonu...

journal_title：International journal of antimicrobial agents

authors： Scaglione F,Berrino L

更新日期：2012-06-01 00:00:00

abstract：:The presence of the plasmid-mediated quinolone resistance determinants qnrA, qnrB, qnrS and aac(6')-Ib-cr was evaluated in a collection of 382 isolates of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae collected between February and March 2006 for the nationwide Spanish GEIH-...

journal_title：International journal of antimicrobial agents

authors： Briales A,Rodríguez-Martínez JM,Velasco C,de Alba PD,Rodríguez-Baño J,Martínez-Martínez L,Pascual A

更新日期：2012-05-01 00:00:00

abstract：:Many studies have demonstrated that sub-minimum inhibitory concentrations (sub-MICs) of antimicrobial agents can inhibit bacterial biofilm formation. However, the mechanisms by which antimicrobial agents at sub-MICs inhibit biofilm formation remain unclear. At present, most studies are focused on Gram-negative bacteri...

journal_title：International journal of antimicrobial agents

authors： Dong L,Tong Z,Linghu D,Lin Y,Tao R,Liu J,Tian Y,Ni L

更新日期：2012-05-01 00:00:00